Product Type: Inhibitor
CAS No.: 143-67-9
MolecularFormula: C46H58N4O9•H2SO4
Molecular Weight: 909,1
Source: Synthetic
Purity: ≥98%
Solubility: Soluble in DMSO, methanol or water (25 mg/ml).
Appearance: White powder.
PubChem CID: 5388983
Scientific Background: Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with lysosomes.
References: 1. Veldhoen R.A., et al. (2013) Oncogene. 32(6): 736-46.2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.