Vismodegib (GDC-04491) , CAS 879085-55-9

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Biological Activity: Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, with IC50 values of 1.4 and 3.0 µM, respectively.

CAS Number: 879085-55-9

Description: Vismodegib (GDC-0449) is a potent hedgehog (Hh) signaling pathway inhibitor.

Format: A crystalline solid

Purity: ≥99% by HPLC

Solubility: Soluble in DMSO at 200 mg/ml; soluble in ethanol at 10 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Von Hoff, D.D., et al. N. Engl. J. Med. 361: 1164-1172 (2009).
2. Zhang, Y., et al. Neoplasia 11: 96-101 (2009).

• Artikelnummer: BPS27015
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27015
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK