Product Type: Inhibitor
CAS No.: 6754-58-1
MolecularFormula: C21H22O5
Molecular Weight: 354,4
Source: Synthetic
Purity: ≥98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml)
Appearance: Yellow solid
PubChem CID: 639665
Scientific Background: Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2).
References: 1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900.2. Vene R., et al. (2012) Mol. Med. 18: 1292.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.