YES1 Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Description: Proto-oncogene tyrosine-protein kinase YES1 has been implicated in regulation of cell growth and survival, apoptosis, cell-cell adhesion, and differentiation. It has been identified as a potential target in basal-like breast cancers. The YES1 Assay Kit is designed to measure YES1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The YES1 Assay Kit comes in a convenient 96-well format, with enough purified recombinant YES1 enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.

Storage Stability: Up to 6 months when stored as recommended.

Warnings: Avoid multiple freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Hamamura K., Tsuji M., et al. Functional Activation of Src Family Kinase Yes Protein is Essential for the Enhanced Malignant Properties of Human Melanoma Cells Expressing Ganglioside GD3; 2011, J.] Biol. Chem.] 286: 18526-18537.
2. Bilal, E., Alexe G., et al. Identification of the YES1 Kinase as a Therapeutic Target in Basal-Like Breast Cancers; 2010, Genes & Cancer Oct; 1(10): 1063-1073.

• Artikelnummer: BPS79681
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79681
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK