YTHDF1 Polyclonal Antibody, Rabbit

Abbreviation: YTHDF1

Target Synonym: YTHDF1;C20orf21

Conjugation: Unconjugated

UNIProt ID: Q9BYJ9

Background: Specifically recognizes and binds N6-methyladenosine (m6A-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3 shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human YTHDF1

Dilution: WB 1:500-1:2000,IHC 1:50-1:200

• Artikelnummer: ELSE-AB-93227-120
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-93227-120
• Green Labware: Nein
• Verpackungseinheit: 120 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit