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eGFP/Firefly Luciferase BCMA Knockout MM.1S Cell Line
eGFP/Firefly Luciferase BCMA Knockout MM.1S Cell Line
Artikelnummer
BPS82732
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Application: Control in cell killing assays.Suitable as a B-cell target of CAR-T or CAR-NK cells during optimization of CAR design.
Background: B-Cell Maturation Antigen (BCMA), also known as CD269, is a cell surface receptor of the TNF receptor superfamily that recognizes B-Cell Activating Factor (BAFF). BCMA is preferentially expressed on mature B-lymphocytes and Multiple Myeloma (MM) cells. BCMA is a highly attractive target antigen for immunotherapy not only because of its restricted expression in nonmalignant tissue, but also due to its almost universal expression on MM cells. Pre-clinical studies using CAR (Chimeric Antigen Receptor) T-cells targeting BCMA have demonstrated anti-MM activity, and in 2017, the FDA granted BCMA CAR T-Cell immunotherapy the breakthrough designation in treating Multiple Myeloma. MM.1S cells are multiple myeloma human B lymphoblasts. The parent cell line MM.1 was established from the peripheral blood of a multiple myeloma patient who had become resistant to steroid-based therapy. MM.1S cells are sensitive to dexamethasone.
Description: eGFP/Firefly Luciferase BCMA Knockout MM.1S Cell Line is a MM.1S cell Line constitutively expressing firefly (Photinus pyralis) luciferase and the enhanced GFP (eGFP) cassette under the control of a CMV promoter, where BCMA (B-Cell Maturation Antigen, or CD269) has been genetically removed using CRISPR/Cas9 genome editing. This cell line was generated by using the eGFP/Firefly Luciferase Lentivirus (BPS Bioscience #79980).
Host Cell Line: MM.1S human B lymphoblasts, suspension
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains >1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
Application: Control in cell killing assays.Suitable as a B-cell target of CAR-T or CAR-NK cells during optimization of CAR design.
Background: B-Cell Maturation Antigen (BCMA), also known as CD269, is a cell surface receptor of the TNF receptor superfamily that recognizes B-Cell Activating Factor (BAFF). BCMA is preferentially expressed on mature B-lymphocytes and Multiple Myeloma (MM) cells. BCMA is a highly attractive target antigen for immunotherapy not only because of its restricted expression in nonmalignant tissue, but also due to its almost universal expression on MM cells. Pre-clinical studies using CAR (Chimeric Antigen Receptor) T-cells targeting BCMA have demonstrated anti-MM activity, and in 2017, the FDA granted BCMA CAR T-Cell immunotherapy the breakthrough designation in treating Multiple Myeloma. MM.1S cells are multiple myeloma human B lymphoblasts. The parent cell line MM.1 was established from the peripheral blood of a multiple myeloma patient who had become resistant to steroid-based therapy. MM.1S cells are sensitive to dexamethasone.
Description: eGFP/Firefly Luciferase BCMA Knockout MM.1S Cell Line is a MM.1S cell Line constitutively expressing firefly (Photinus pyralis) luciferase and the enhanced GFP (eGFP) cassette under the control of a CMV promoter, where BCMA (B-Cell Maturation Antigen, or CD269) has been genetically removed using CRISPR/Cas9 genome editing. This cell line was generated by using the eGFP/Firefly Luciferase Lentivirus (BPS Bioscience #79980).
Host Cell Line: MM.1S human B lymphoblasts, suspension
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains >1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
| Artikelnummer | BPS82732 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 82732 |
| Verpackungseinheit | 2 vials |
| Mengeneinheit | PAK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
