BCA-1/ BLC (CXCL13), human recombinant (rHuBCA-1)

Kategorie: Cytokines

Formulation: purified

Storage: -20°C

Weight: 10.3 kD

Description: Recombinant human CXCL13 produced in E.coli is a single,non-glycosylated, polypeptide chain containing 87 amino acids and having a molecular mass of 10.3 kDa. BCA-1 is a CXC chemokine that is highly expressed in the secondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt's lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR-1, now designated CXCR-5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.

• Artikelnummer: BOL97377.20
• Hersteller: Biomol
• Hersteller Artikelnummer: 97377.20
• Green Labware: Nein
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Human Gene ID: 10563
• Wirt: Escherichia Coli