Cardiotrophin-Like Cytokine Factor 1, His Tag, human recombinant (rHuCLCF-1-His)

Kategorie: Cytokines

Formulation: solution

Storage: -20°C

Weight: 24600 D

Purity: >90%

Description: Human recombinant CLCF1 produced in E.coli is a single, non-glycosylated polypeptide chain containing 219 amino acids (28-225) and having a molecular mass of 24.6kDa. CLCF1 is fused to a 21 amino acid His-tag at N-terminus. Cardiotrophin-like cytokine factor 1 (CLCF1) is a member of the interleukin 6 family of cytokines, which are involved in cell signaling via phosphorylation of gp130. CLCF1 has a sequence of 225 amino acids with a 27 aa signal peptide, having a molecular mass of 22kDa in the mature form, and the maximum homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 is actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in the CLCF1 gene cause cold-induced sweating syndrome 2 (CISS2). The CISS2 syndrome is typified by profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.

• Artikelnummer: BOL97427.1
• Hersteller: Biomol
• Hersteller Artikelnummer: 97427.1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Human Gene ID: 23529
• Wirt: Escherichia Coli