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Interleukin-2, equine recombinant (reIL-2)
Interleukin-2, equine recombinant (reIL-2)
Artikelnummer
BOL97647.20
Verpackungseinheit
20 µg
Hersteller
Biomol
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Kategorie: Cytokines
Formulation: lyophilized
Storage: -20°C
Weight: 14900 D
Purity: >97%
Description: Recombinant equine Interleukin-2 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids (with a substitution of S for C - at position 141 compared with the wild type IL2) and having a molecular mass of 14.9 kDa. IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin-4 (IL4) and interleukin-7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 1.0 µg/ml, corresponding to a specific activity of > 1000 IU/mg.
Formulation: lyophilized
Storage: -20°C
Weight: 14900 D
Purity: >97%
Description: Recombinant equine Interleukin-2 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids (with a substitution of S for C - at position 141 compared with the wild type IL2) and having a molecular mass of 14.9 kDa. IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin-4 (IL4) and interleukin-7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 1.0 µg/ml, corresponding to a specific activity of > 1000 IU/mg.
| Artikelnummer | BOL97647.20 |
|---|---|
| Hersteller | Biomol |
| Hersteller Artikelnummer | 97647.20 |
| Green Labware | Nein |
| Verpackungseinheit | 20 µg |
| Mengeneinheit | STK |
| Reaktivität | Horse (Equine) |
| Human Gene ID | 100034204 |
| Wirt | Escherichia Coli |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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