Interleukin-28A, mouse recombinant (rmIL-28A)

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 19700 D

Purity: >95%

Description: Recombinant mouse Interleukin-28A produced in E. coli is a single, non-glycosylated polypeptide chain containing 174 amino acids and having a total molecular mass of 19.7 kDa. IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity. IL-28A acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda 3 are closely positioned genes on human chromosome 19. IL-28A induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-28A is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis(EMC) virus is less than 3 ng/ml, corresponding to a specific activity of > 3.3 × 105 IU/mg.

• Artikelnummer: BOL97650.20
• Hersteller: Biomol
• Hersteller Artikelnummer: 97650.20
• Green Labware: Nein
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Human Gene ID: 330496
• Wirt: Escherichia Coli