Interleukin-33, mouse recombinant (rmIL-33)

Kategorie: Cytokines

Formulation: purified

Storage: -20°C

Weight: 17500 D

Purity: >97%

Description: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Induces T helper type 2-associated cytokines. (www.uniprot.org) Mouse recombinant Interleukin-33 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 17.5 kDa. Interleukin-33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T-cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

• Artikelnummer: BOL97269.2
• Hersteller: Biomol
• Hersteller Artikelnummer: 97269.2
• Verpackungseinheit: 2 µg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Wirt: Escherichia Coli