Interleukin-33, rat recombinant (rrIL-33)

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 17400 D

Purity: >95%

Description: Rat recombinant IL-33 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids and having a molecular mass of 17.4kDa. Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

• Artikelnummer: BOL97510.2
• Hersteller: Biomol
• Hersteller Artikelnummer: 97510.2
• Green Labware: Nein
• Verpackungseinheit: 2 µg
• Mengeneinheit: STK
• Reaktivität: Rat (Rattus)
• Human Gene ID: 361749
• Wirt: Escherichia Coli