Interleukin-36 Gamma 152 a.a., human recombinant (rHuIL-36G-152aa)

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 17000 D

Purity: >95%

Description: Human recombinant IL36G (152) produced in E.coli is a single, non-glycosylated, polypeptide chain containing 152 amino acids and having a molecular mass of 17.0kDa. IL-36gamma belongs to the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36 Ra (IL-1F5), IL-36a (IL-1F6), IL-36b (IL-1F8), IL-37 (IL-1F7) and IL-1F10.). The IL-1 family members display a 12 b-strand, b-trefoIL-configuration, and are thought to have ascended from a mutual ancestral gene. IL-36g is an 18-22 kDa, 169aa intracellular and secreted protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation sites. Human IL-36g shares 58%- 69% aa sequence homology with mouse, rat, bovine and equine IL-36g, and 23 - 57% aa sequence homology with other family members. The IL-36g receptor is a mixture of IL-1 Rrp2, mostly located in epithelia and keratinocytes, and the extensively expressed IL-1 RAcP. All IL-36 (a, b and g) activate N F-kappaB and MAPK pathways in an IL-1 Rrp2 dependent reaction. Additionally, IL-36g induces production of inflammatory cytokines and chemokines like CXCL8/IL-8.

• Artikelnummer: BOL97515.10
• Hersteller: Biomol
• Hersteller Artikelnummer: 97515.10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Human Gene ID: 56300
• Wirt: Escherichia Coli