Kategorie: Cytokines
Formulation: sterile solution
Storage: -20°C
Weight: 15000 D
Description: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 77 amino acids (fragment 23-99) with an amino-terminal hexahistidine tag.