Macrophage Inflammatory Protein-3 (CCL23), human recombinant (rHuMIP-3)

Macrophage Inflammatory Protein-3 (CCL23), human recombinant (rHuMIP-3)
Artikelnummer
BOL97252.20
Verpackungseinheit
20 µg
Hersteller
Biomol

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Kategorie: Cytokines

Formulation: purified

Storage: -20°C

Weight: 11300 D

Purity: >97%

Description: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. (www.uniprot.org) CCL23 (MIP-3) is a ligand for the CCR1chemokine receptor. CCL23 is one of several cytokine genes clustered on the q-arm of chromosome 17, in a locus containing several other CC chemokines. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but not activated lymphocytes. Furthermore, it was shown that MIP-3 inhibits colony formation of bone marrow myeloid immature progenitors. MIP-3 is mainly expressed in lung and liver tissue, but can be also found in bone marrow and placenta, as well as in some cell lines of myeloid origin. MIP-3 may be involved in the malignant progression of certain human cancer cells which overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. MIP-3 may also be involved in angiogenesis via upregulation of matrix metalloproteinase MMP-2 expression.
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Artikelnummer BOL97252.20
Hersteller Biomol
Hersteller Artikelnummer 97252.20
Verpackungseinheit 20 µg
Mengeneinheit STK
Reaktivität Human
Wirt Escherichia Coli
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