Platelet Derived Growth Factor-D, His tag, human recombinant (rHuPDGFD-His)

Kategorie: Cytokines

Formulation: solution

Storage: -20°C

Weight: 16600 D

Purity: >90%

Description: Human recombinant PDGFD produced in E.coli is a single polypeptide chain containing 146 amino acids (250-370) and having a molecular mass of 16.6 kDa. PDGFD is fused to a 25 amino acid His-tag at N-terminus. Platelet-derived growth factor D (PDGFD) belongs to the platelet-derived growth factor family. PDGFD gene product only forms homodimers and, thus, does not dimerize with the other 3 family members. PDGFD has an imperative role in wound healing. PDGFD induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. PDGFD initiates events which lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. The 4 members of the PDGF family are mitogenic factors for cells of mesenchymal origin and are distinguished by a core motif of eight cysteines, 7 of which are found in this factor. PDGFD differs from alpha and beta members of this family by having an odd N-terminal domain, the CUB domain.

• Artikelnummer: BOL97588.1
• Hersteller: Biomol
• Hersteller Artikelnummer: 97588.1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Human Gene ID: 80310
• Wirt: Escherichia Coli