Platelet Factor-4 (CXCL4), mouse recombinant (rmPF4)

Kategorie: Cytokines

Formulation: purified

Storage: -20°C

Weight: 8200 D

Purity: >97%

Description: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity). (www.uniprot.org) Recombinant mouse CXCL4 produced in E.coli is a single, non-glycosylated polypeptide chain containing 73 amino acids and having a molecular mass of 8.2 kDa. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

• Artikelnummer: BOL97334.1
• Hersteller: Biomol
• Hersteller Artikelnummer: 97334.1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Wirt: Escherichia Coli