Stromal Cell-Derived Factor-1 alpha (CXCL12), human recombinant (rHuSDF-1a)

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 8004 D

Description: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. (www.uniprot.org) Produced in E.coli as a non-glycosylated, polypeptide chain containing 68 amino acids. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development.

• Artikelnummer: BOL94842.2
• Hersteller: Biomol
• Hersteller Artikelnummer: 94842.2
• Verpackungseinheit: 2 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Wirt: Escherichia Coli