Uteroglobin, human recombinant

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 15800 D

Purity: >98%

Description: Uteroglobin human recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 70 amino acids and having a molecular mass of 15.8 kDa. Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 µg/ml, corresponding to a specific activity of > 200 IU/mg.

• Artikelnummer: BOL97651.1
• Hersteller: Biomol
• Hersteller Artikelnummer: 97651.1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Human Gene ID: 7356
• Wirt: Escherichia Coli