B2M Knockout THP-1 Cell Line

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Applications: Study the consequences of B2M knock-downStudy T cell activation, antigen presentation, and immune responses

Background: THP-1 cells are monocytes, derived from an acute monocytic leukemia patient. Beta-2-Microglobulin is a required component of Major Histocompatibility Complex (MHC) class 1 molecules, which present peptide fragments from within the cell to cytotoxic T cells as part of the adaptive immune system. B2M plays an essential role both in governing MHC class I molecule stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Description: B2M (Beta-2-Microglobulin) has been genetically removed by CRISPR/Cas9 genome editing from THP-1 cells.

Host Cell Line: THP-1, monocyte, suspension

Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.

Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)

Uniprot: P61769

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

• Artikelnummer: BPS78389
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78389
• Verpackungseinheit: 2 vials
• Mengeneinheit: PAK
• Wirt: Human