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CD27 CHO-K1 Stable Recombinant Cell Line
CD27 CHO-K1 Stable Recombinant Cell Line
Artikelnummer
BPS60624
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Background: CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes theT cell co-stimulatory receptors OX40, 4-1BB and herpesvirus entry mediator (HVEM). CD27 isexpressed on various types of T cells, B cells and a subset of natural killer cells. It activates NF-B and MAPK/JNK signaling upon interaction with its TNF-like ligand, CD70, which is expressedby numerous tumor cells. Adaptor proteins TRAF2 and TRAF5 can also stimulate CD27signaling. Activation of CD27 leads to lymphoid proliferation, differentiation, apoptosis, and theinduction of long-term memory. The CD27/CD70 pathway is a key target for the development oftreatments for cancer and inflammatory diseases.
Description: CHO-K1 cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by real time qPCR and Western blot.Screening for antibodies recognizing CD27 and screening antibodies for binding affinities. Since
CHO-K1 cells do not express endogenous CD27, this cell line serves as an excellent model for
studying changes in CD27-mediated signaling pathways, such as NF-B, MAPK and
SAPK/JNK.
Format: Aqueous solution containing DMSO
Host Cell Line: CHO-K1
Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, Cat.#LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set(Lonza, Cat. #LT07-518) was used as a positive control.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Supplied As: Each vial contains ~2 X 106 cells in 1 ml of 10% DMSO.
Biosafety Level: BSL-1
References: 1. Akiba H et.al. (1998) CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-B and stress-activated protein kinase/ c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-B inducing kinase. J. Biol. Chem. 273: 13353
2. Yamamoto H et.al. (1998) NF-B activation in CD27 signaling: Involvement of TNF receptor-associated factor in its signaling and identification of functional region of CD27. J. Immunology 161: 4753-4759
Background: CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes theT cell co-stimulatory receptors OX40, 4-1BB and herpesvirus entry mediator (HVEM). CD27 isexpressed on various types of T cells, B cells and a subset of natural killer cells. It activates NF-B and MAPK/JNK signaling upon interaction with its TNF-like ligand, CD70, which is expressedby numerous tumor cells. Adaptor proteins TRAF2 and TRAF5 can also stimulate CD27signaling. Activation of CD27 leads to lymphoid proliferation, differentiation, apoptosis, and theinduction of long-term memory. The CD27/CD70 pathway is a key target for the development oftreatments for cancer and inflammatory diseases.
Description: CHO-K1 cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by real time qPCR and Western blot.Screening for antibodies recognizing CD27 and screening antibodies for binding affinities. Since
CHO-K1 cells do not express endogenous CD27, this cell line serves as an excellent model for
studying changes in CD27-mediated signaling pathways, such as NF-B, MAPK and
SAPK/JNK.
Format: Aqueous solution containing DMSO
Host Cell Line: CHO-K1
Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, Cat.#LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set(Lonza, Cat. #LT07-518) was used as a positive control.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Supplied As: Each vial contains ~2 X 106 cells in 1 ml of 10% DMSO.
Biosafety Level: BSL-1
References: 1. Akiba H et.al. (1998) CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-B and stress-activated protein kinase/ c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-B inducing kinase. J. Biol. Chem. 273: 13353
2. Yamamoto H et.al. (1998) NF-B activation in CD27 signaling: Involvement of TNF receptor-associated factor in its signaling and identification of functional region of CD27. J. Immunology 161: 4753-4759
| Artikelnummer | BPS60624 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 60624 |
| Verpackungseinheit | 2 vials |
| Mengeneinheit | PAK |
| Wirt | Hamster |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
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