Claudin-18 Isoform 1 CHO Cell Line

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Applications: Test antibodies against claudin 18.1Screen inhibitors or neutralizing antibodies against claudin 18.1

Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin 18.1, which is found primarily in the lung, and claudin 18.2, which is expressed exclusively in the stomach. In claudin 18-deficient studies, claudin 18.1 was identified as a regulator of normal lung homeostasis as its deficiency promoted the proliferative state of malignant cells found in lung adenocarcinomas.¹ Therefore, claudin-18.1 may be a potential therapeutic target in cancer. ¹

Description: Recombinant clonal CHO cell line stably expressing full-length human claudin 18.1 (claudin 18 isoform 1, CLDN18, gene accession number NM_016369.4). The stable clonal cell line was selected for high levels of claudin 18.1 expression compared to the parental CHO-K1 cell line.

Host Cell Line: CHO

Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.

Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long-term storage.

Supplied As: Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)

Uniprot: P56856

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

References: Kyuno D., Takasawa A., Kikuchi S., Takemasa I., Osanai M., Kojima T. Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells. Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1863, Issue 3, 2021, 183503

• Artikelnummer: BPS78361
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78361
• Verpackungseinheit: 2 vials
• Mengeneinheit: PAK
• Wirt: Hamster