Product Type: Inhibitor
CAS No.: 331771-20-1
MolecularFormula: C29H31N5O4
Molecular Weight: 513,6
Source: Synthetic
Purity: ≥98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (50mg/mL)
Appearance: Orange solid
PubChem CID: 9914412
Scientific Background: ZM447439 is a potent and selective inhibitor of Aurora B kinase. ZM447439 induces cell growth arrest mid-way through mitosis, and therefore effectively activates apoptosis.
References: 1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669. 2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.