Clone Name: AT4F8
Light Chain: Kappa
Calculated MW: 29
Specificity/Sensitivity: Based on internal testing result, this antibody does not cross react with human 14-3-3 zeta, human 14-3-3 beta, human 14-3-3 eta, human 14-3-3 gamma, human 14-3-3 sigma, and human 14-3-3 tau protein.
Form: Liquid
Buffer (with preservative): PBS, 10% Glycerol, 0.02% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot ID: P62258
Antigen Species: Human
Immunogen: The clone AT4F8 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human 14-3-5 epsiilon protein.
Purification: Protein A Purified
Conjugation: Unconjugated
Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
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