Product Description: 2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases[1][2][3].
Applications: Cancer-programmed cell death
Formula: C27H36N10O14P2S2
References: [1]Zhang X, et al GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35/[2]Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175./[3]Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.
CAS Number: 2586047-11-0
Molecular Weight: 850.71
Research Area: Cancer; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Drug-Linker Conjugates for ADC;STING
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