22-Oxacalcitriol, CAS 103909-75-7

22-Oxacalcitriol, CAS 103909-75-7
SKU
CAY10794-10
Packaging Unit
10 mg
Manufacturer
Cayman Chemical

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Formulation: A crystalline solid

Formal Name: 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol

Purity: ≥95%

Formula Markup: C26H42O4

Formula Weight: 418,6

Shelf life (days): 730

CAS Number: 103909-75-7

Notes: Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis.{22231,22230} First reported to avoid hypercalcemia, an undesirable side effect of calcitriol, prolonged treatment with 22-oxalcalcitriol can be calcemic in humans.{22231,22230} Analogs of calcitriol, including 22-oxacalcitriol, inhibit human keratinocyte proliferation while inducing differentiation and is beneficial in treating psoriasis.{22227,22226} 22-Oxacalcitriol also blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells.{22229}
More Information
SKU CAY10794-10
Manufacturer Cayman Chemical
Manufacturer SKU 10794-10
Package Unit 10 mg
Quantity Unit STK
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