Application Note: ICC/IF: 10µg/ml. IHC-P: 2µg/ml. FACS: 10ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 53
Specificity/Sensitivity: This antibody is expected to recognize both reported isoforms (NP_000612.1; NP_001159419.1).
Form: Liquid
Buffer (with preservative): Tris saline pH7.3, 0.5% BSA, 0.02% sodium azide.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot ID: P28223
Antigen Species: Human
Immunogen: Peptide with sequence C-QRSIHREPGSYTGR (aa296-309), from the internal region of the protein sequence according to NP_000612.1; NP_001159419.1.
Purification: Ammonium sulphate precipitation followed by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: 5-hydroxytryptamine receptor 2A
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