A-771726, CAS 163451-81-8

Formulation: A crystalline solid

Formal Name: 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide

Purity: ≥98%

Formula Markup: C12H9F3N2O2

Formula Weight: 270,2

Shelf life (days): 1460

CAS Number: 163451-81-8

Notes: A-771726 is an active metabolite of the prodrug leflunomide (Item No. 14860) that inhibits dihydroorotate dehydrogenase (DHODH; IC50 = 0.23 µM).{60466} A-771726 inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively).{22722} It inhibits the proliferation of isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 25 and 100 µM.{60467} A-771726 (3 and 10 mg/kg) delays disease onset and decreases neurological deficits in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by complete Freund’s adjuvant (CFA) and M. tuberculosis.{60468} Formulations containing teriflunomide have been used in the treatment of multiple sclerosis.

• SKU: CAY14404-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14404-50
• Package Unit: 50 mg
• Quantity Unit: STK