Clone Name: AT1E10
Light Chain: Kappa
Application Note: WB: Recommended starting dilution is 1:500.. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 14
Specificity/Sensitivity: Based on internal testing result, this antibody does not cross react with human beta- and gamma-synuclein protein.
Form: Liquid
Buffer (with preservative): PBS, 10% Glycerol, 0.02% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Uniprot ID: P37840
Antigen Species: Human
Immunogen: The clone AT1E10 is derived from hybridization of mouse F2 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein.
Purification: Protein A Purified
Conjugation: Unconjugated
Full Name: synuclein alpha
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