Product Type: Agonist.
CAS No.: 102121-60-8.
MolecularFormula: C22H25NO3.
Molecular Weight: 351,4.
Source: Synthetic.
Purity: >98% (HPLC) NMR (Conforms).
Solubility: May be dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml).
Appearance: Off-white powder.
PubChem CID: 2126.
Scientific Background: AM-580, a benzoic derivative of retinoic acid and a selective RAR-α agonist, has been shown to significantly reduce the production of Th1 cytokines but promote Th2 cytokines in human PBMCs7 and to inhibit microglial activation, thus acting beneficially in Alzheimer's disease treatment. It also is known to inhibit tumor cell proliferation and induces apoptosis.
References: 1. Wang O., Thome R., Rostami A., Ma C-G., Zhang G-X. (2019) Nature. 16: 727-729. 2. Bosch A., et al. (2012) Breast Cancer Res. 14(4): R121.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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