Aminooxy-PEG3-azide, CAS 1306615-51-9

Product Description: Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C8H18N4O4

References: [1]Chanhyuk KIM, et al. Optimized chimeric receptor t cell switches and uses thereof. WO2016168766A1./[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

CAS Number: 1306615-51-9

Molecular Weight: 234.25

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• SKU: MEXHY-126949-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-126949-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK