Formulation: A 10 mM solution in DMSO
Shelf life (days): 1460
Notes: The Anti-Inflammatory Screening Library consists of 3 plates and contains approximately 235 anti-inflammatory and related compounds in a 96-well Matrix™ tube rack format as 10 mM stock solutions in DMSO. This library includes inhibitors of pro-inflammatory cytokine production, macrophage and T cell activation, cytokine storm receptor signaling, the NLRP3 inflammasome, NF-κB signaling, and kinases involved in canonical and non-canonical inflammatory signaling pathways. It also includes corticosteroids, glucocorticoids, and inhibitors of enzymes involved in inflammatory lipid mediator production and metabolism, such as COX-1 and COX-2, 5-lipoxygenase (5-LO), microsomal prostaglandin E synthase-1 (mPGES-1), cytosolic phospholipase A2 (cPLA2), and soluble epoxide hydrolase (sEH). Additional targets include enzymes and receptors involved in NETosis, coagulation, and platelet aggregation. Stability data is not available for individual compounds as supplied in the screening library. Panels are routinely re-evaluated to include new catalog introductions as the research evolves.
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