Anti-Mouse CD183 In Vivo Antibody (CXCR3-173) - Ultra-Low Endotoxin

Anti-Mouse CD183 In Vivo Antibody (CXCR3-173) - Ultra-Low Endotoxin, Host: Armenian Hamster, Armenian Hamster IgG
SKU
ICH1201UL-50MG
Packaging Unit
50mg
Manufacturer
Ichorbio

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Target: CD183.

Clone: CXCR3-173.

Specificity: CXCR3-173 activity is directed against murine CD183 (CXCR3).

Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution: CXCL3 is expressed on primary memory phenotype CD4+ and CD8+ T cells, naturally occurring CD4+CD25+ Foxp3+ regulatory T cells, natural killer (NK) T cells, and approximately 25% of NK cells. CXCR3-173 recognizes an epitope of CXCR3 expressed on the surface of activated mouse splenocytes.

Background: Hamsters were tested by ELISA for seropositivity against CXCR3 peptide and hybridomas were generated, screened by FACS, purified, and tested for: staining, CXCR3 blockade in vitro, and endotoxin levels. CXCR3-173 detects the native form of CXCR3, and therefore does not work in Western blotting.CXCR3-173 has potential use in immunotherapeutic approaches to inhibit transplant rejection and immune related diseases. In vitro, CXCR3-173 blocks chemotaxis in response to CXCL10 or CXCL11 but not CXCL9. In vivo, CXCR3-173 prolongs both cardiac and islet allograft survival in a manner further enhanced by rapamycin.

Immunogen: CXCR3-173 was generated by immunizing Armenian hamsters with a peptide sequence unique to mouse CXCR3 which encompasses amino acids 1-37.

Concentration: ≥ 2.0 mg/ml.

Formulation: Sterile, preservative-free, solution in PBS. BSA and Azide free.

Purity: >98% by SDS-PAGE and HPLC.

Endotoxin: ≤ 0.5 EU/mg as determined by the LAL method.

Aggregation: Aggregation level ≤ 1%.

Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
More Information
SKU ICH1201UL-50MG
Manufacturer Ichorbio
Manufacturer SKU ICH1201UL-50MG
Package Unit 50mg
Quantity Unit STK
Reactivity Mouse (Murine)
Clonality Monoclonal
Application Flow Cytometry, Neutralization
Isotype Armenian Hamster IgG
Host Hamster
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