Target: CD71.
Clone: OX-26.
Specificity: Clone OX-26 reacts with rat CD71 (TfR1).
Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: CD71 is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors.
Background: CD71 is a transferrin receptor on the cell surface that mediates the uptake of transferrin-iron complexes, thereby mediating cellular proliferation. CD71 is a homodimeric glycoprotein containing 760 amino acids and it binds to diferric transferrin. Binding by diferric transfferin causes CD71 to be internalized, and diferric iron is subsequently released. CD71 is highly expressed on malignant cells, as iron uptake is necessary for aberrant cell proliferation.
Concentration: ≥ 2.0 mg/ml.
Formulation: Sterile, preservative-free, solution in PBS. BSA and Azide free.
Purity: >98% by SDS-PAGE and HPLC.
Endotoxin: ≤ 0.5 EU/mg as determined by the LAL method.
Aggregation: Aggregation level ≤ 1%.
Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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