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Encompassing Amino Acids: 2433-2548
Applications: Useful for the study of bromodomainbinding assays, screening inhibitors, andselectivity profiling.
Description: Human bromodomain ash1 (absent, small or homeotic)-like (ASH1L), also known as, KMT2H, ASH1-Like Protein, Ash1, huASH1 and EC 2.1.1.43, GenBank Accession No. NM_018489, a.a. 2433 - 2548 corresponding to single bromodomain, with N-terminal His-tag, MW = 14.2 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Genbank: NM_018489
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q9NR48
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Muller, S., et al., Expert Rev. Mol. Med. 2011;13:1-21.
2. An, S., et al., J. Biol Chem. 2011;286(10):8369-8374.Application Reference(s):The epigenetically active small chemical N-methyl pyrrolidone (NMP) prevents estrogen depletion induced osteoporosis (2015)
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