Azido-PEG3-Val-Cit-PAB-PNP, CAS 2055047-18-0

Product Description: Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C34H47N9O12

References: [1]Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32./[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

CAS Number: 2055047-18-0

Molecular Weight: 773.79

Compound Purity: 99.09

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: ADC Linker;PROTAC Linkers

• SKU: MEXHY-140150-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-140150-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK