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Application: Useful for blocking assays.
Assay Conditions: Assay was done according to BCMA:APRIL[Biotinylated] Inhibitor Screening Assay Kit (BPS Bioscience #79722) using various amounts of BAFF/APRIL Dual Antagonist.
Background: BAFF (TNF family ligand B-cell Activating Factor), also known as BLyS, TALL-1 or CD257, is encoded by the TNFSF13B gene and is a Type II membrane-bound protein, which can be released as a soluble ligand upon proteolytic processing. This cytokine is a ligand for the receptors Transmembrane Activator and CAML Interactor (TACI or TNFRSF13B), BAFF Receptor (BAFFR, or TNFRSF13C) and B-cell Maturation Antigen (BCMA, TNFRSF17). These interactions promote cell survival and play a crucial role in B cell development. APRIL (A proliferation-inducing ligand), also known as TNSF13 or CD256, activates a signaling pathway that participates in the regulation of B-cell development, autoimmunity, and long-term plasma cell survival. APRIL expression is significantly elevated in multiple myeloma (MM), and it has been demonstrated that activation of BCMA by APRIL promotes tumor growth, chemoresistance, and immunosuppression in the bone marrow microenvironment. Anti-APRIL monoclonal antibodies have recently progressed to clinical trials for MM. The development of a modified TACI (transmembrane activator and CAML interactor) domain resulted in Povetacicept, or ALPN-303, a dual inhibitor of APRIL and BAFF, with potential applications in the treatment of autoimmune disorders.
Description: BAFF/APRIL Dual Antagonist is a fusion protein composed of TACI (transmembrane activator and CAML interactor), and the Fc domain of human IgG1. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: Fc Fusion (Human IgG1)
Uniprot: O14836
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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