Specificity: Immuno-staining of beta-catenin and E-cadherin is helpful in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. Immunogen: A synthetic peptide from the middle of beta-Catenin (p120) protein