Beta-Lapachone, CAS 4707-32-8

DNA topoisomerase I inhibitor

Product Type: Inhibitor

CAS No.: 4707-32-8

MolecularFormula: C15H14O3

Molecular Weight: 242,3

Source: Synthetic

Purity: >98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (35 mg/ml); or Ethanol (15 mg/ml)

Appearance: Orange powder

PubChem CID: 3885

Scientific Background: β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. A novel DNA topoisomerase I inhibitor which unlike camptothecindoes not stabilize the cleavable complex indicating a novel mode of action (1). Induces apoptosis in a number of cancer cell lines (2). In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms (3) resulting in the production of reactive oxygen species (4). Suppresses radiation-induced activation of NFĸB (5). Attenuates cognitive impairment and inflammation in amyloid-induced mouse model.

References: 1. CJ Li et al. J. Biol. Chem. 1993 268:224632. SM Wuerzberger et al. Cancer Res. 1998 58:18763. JJ Pink et al. J. Biol. Chem. 2000 275:54164. D Siegel et al. Biochem. Pharmacol. 2012 83:10335. GZ Dong et al. Exp. Mol. Med. 2010 42:327

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-589-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-589-5MG
• Package Unit: 5 mg
• Quantity Unit: STK