Formulation: This vial contains 100 µg of protein G-purified monoclonal antibody
Immunogen: BLT1 receptor-expressing cells
Clone Designation: 7A8
Shelf life (days): 1095
Notes: BLT1 is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4) with roles in the pathogenesis of various inflammatory and immune diseases.{55898,68495} It is expressed in most immune cells, including neutrophils, macrophages, eosinophils, and T cells, as well as certain non-immune cells, such as endothelial cells, fibroblasts, and smooth muscle cells.{68495} Binding of LTB4 to BLT1 during the onset of inflammation induces early recruitment and activation of neutrophils and inflammatory polarization of macrophages.{68495,68496} BLT1 activation also mediates effector T cell recruitment, providing a link between innate and adaptive immunity during T cell-mediated inflammation. Knockdown of Ltbr41, the gene encoding BLT1, improves glucose tolerance and reduces hyperinsulinemia in a mouse model of high-fat diet-induced obesity.{28488} Ltbr41 knockdown prevents joint immune cell infiltration and the development of arthritis in multiple mouse models of osteoarthritis and rheumatoid arthritis.{68497} Loss of Ltbr41 also increases tumor burden and decreases survival in a mouse model of spontaneous colorectal tumor formation.{68498} Cayman’s BLT1 Receptor (mouse) Monoclonal Antibody (Clone 7AB) can be used for flow cytometry (FC).
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