Formulation: A solid
Formal Name: 1-(4-chlorophenyl)-α-(2-methylpropyl)-cyclobutanemethanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C15H22ClN • HCl
Formula Weight: 288,3
Shelf life (days): 1460
CAS Number: 84484-78-6
Notes: BTS-54-505 is an active metabolite of sibutramine.{62634} It inhibits norepinephrine, serotonin (5-HT), and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively). In vivo, BTS-54-505 prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg) and decreases immobility in the Porsolt learned helplessness test in mice when administered at a dose of 10 mg/kg. BTS-54-505 (10 mg/kg) increases colonic temperature, a marker of thermogenesis, and decreases food intake in rats.{68526}