Target: BubR1 (pSer670).
Conjugate: Unconjugated.
Product Type: Polyclonal.
Immunogen: A phospho-specific peptide corresponding to residues surrounding Ser670 of human BUBR1 (AA667-673).
Swiss-Prot: O60566.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS pH7.4, 50% glycerol, 0.025% Thimerosal.
Specificity: Detects 119 kDa.
Cellular Localization: Cytoplasm, Nucleus.
Tissue Specificity: Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.
Scientific Background: BUBR1 is a protein-serine/threonine kinase. It is an essential component of mitotic checkpoint. It prevents progression of anaphase until all the sister chomatids are connected to spindles by binding to CDC20 to anaphase promoting complex/cycolsome thus inhibiting it. It is also involved in localization of CENPE, a kinetochore motor that performs kinetochore functions. Other functions include suppression of centrosome amplification, negative regulation of PLK1 in intephase and trigger apoptosis in polyploid cells.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
