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Clone Name: HMV363
Light Chain: Kappa
Application Note: IHC-P: 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Positive Control: Normal Pancreas
Negative Control: Normal Colon
Form: Liquid
Buffer (with preservative): PBS, 2% BSA, 0.025% ProClin 300.
Concentration: batch dependent
Background: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Uniprot ID: P01308
Antigen Species: Human
Immunogen: Synthetic peptide corresponding to human c-peptide.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: insulin
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