Clone Name: Calp3d/2C4
Application Note: WB: 1:25–1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 94
Specificity/Sensitivity: This antibody reacts with full-size calpain 3 (94 kD) plus an additional fragment at 30 kD in human skeletal muscle. A band of 94 kD is seen with rabbit and dog muscle while extracts of hamster muscle show reactivity with the 94 kD band and a larger species of approximately 110 kD. This 110 kD band is the principal immunoreactive species seen in rat muscle extracts. This antibody produces no bands with mouse, pig or chicken muscle.,We do not recommend use of this product for Chicken,Mouse,Pig.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.
Concentration:
Background: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Uniprot ID: P20807
Antigen Species: Human
Immunogen: Synthetic peptide containing amino acids 1–19 of the human calpain 3 sequence.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: calpain 3
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