Conjugation: HRP: Horseradish Peroxidase
Description of Target: F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CAPZA3 may play a role in the morphogenesis of spermatid.This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAPZA3
Key Reference: Miyagawa,Y., (2002) Mol. Hum. Reprod. 8 (6), 531-539
Molecular Weight: 33kDa
Peptide Sequence: Synthetic peptide located within the following region:
MTLSVLSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: F-actin-capping protein subunit alpha-3
Protein Size: 299
Purification: Affinity Purified
Subunit: alpha-3
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