CAY10760, CAS 391889-85-3

Formulation: A crystalline solid

Formal Name: 6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone

Purity: ≥98%

Formula Markup: C28H24ClN3O3

Formula Weight: 486

Shelf life (days): 1460

CAS Number: 391889-85-3

Notes: CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).{46810} It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).

• SKU: CAY30532-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30532-1
• Package Unit: 1 mg
• Quantity Unit: STK