Product Type: Blocker
CAS No.: 351424-20-9
MolecularFormula: C15H11Cl2NO4
Molecular Weight: 340,2
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (35 mg/ml)
Appearance: Off-white powder
PubChem CID: 2264067
Scientific Background: CBA is a selective blocker of TRPM4 channels (IC50 = 1.5 M) with no activity at TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a panel of other ion channels and receptors (1). Displays protective effects in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration (2). A highly useful tool for exploring the functions of TRM4 in a variety of cell types (3,4).
References: 1.LC Ozhathil et al. Br. J. Pharmacol. 2018 175:25042.B Bianchi et al. Mol. Brain 2018 11:413.A Borgstrom et al. J. Mol. Biol. 2021 433:1666654.G Diszhazi et al. J. Biol. Chem. 2021 297:101015
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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