CBL blocking peptide

Species: Human

Specificity/Sensitivity: The peptide was used in the production of GTX89954.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservative.

Concentration:

Background: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

Region Sequence: C-REFVSISSPAHVAT

Full Name: Cbl proto-oncogene, E3 ubiquitin protein ligase

• SKU: GTX89954-PEP-100
• Manufacturer: GeneTex
• Manufacturer SKU: GTX89954-PEP-100
• Green Labware: No
• Package Unit: 100 μg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Application: ELISA, Blocking, Affinity Purification
• Human Gene ID: 867