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Encompassing Amino Acids: 2-185(end)
Applications: Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Background: Component of heterochromatin. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Recognizes and binds histone H3 tails methylated at Lys9, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Description: Human chromobox homolog 1 (CBX1), also known as p25beta, M31, HP1-beta, and MOD1, GenBank Accession No. NM_006807, a.a. 2-185(end), with N-terminal GST-tag, MW=48.1 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, and 20% glycerol.
Genbank: NM_006807
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: P83916
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Furuta, K., et al., Chromosoma. 1997
Jun;106(1) :11-9.
2. Ekblad, C.M., et al., EMBO Rep. 2005
Jul;6(7) :675-80.
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