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Encompassing Amino Acids: 20-305
Application: Useful for SDS-PAGE and avidin pull-down assays.
Background: CD123, also known as interleukin 3 receptor alpha (IL3Ra), is a cell surface receptor found in pluripotent progenitor cells and involved in hematopoietic lineage differentiation. It can also be found in basophils, plasmacytoid dendritic cells and dendritic cells. CD123 is overexpressed on leukemic hematopoietic stem cells (HSCs), but not normal HSCs. It has been found in acute myeloid and B-lymphoid leukemias, blastic plasmacytoid dendritic neoplasms (BPDCN), and hairy cell leukemia. This expression profile makes CD123 an attractive target in cancer therapy. CAR-Ts and other therapies targeting CD123 are being evaluated in clinical trials.
Description: Recombinant human CD123 (also known as IL3Ra , interleukin 3 receptor alpha) encompassing amino acids 20-305 (end). This construct contains a C-terminal Avi-Tag™ followed by a C-terminal His-tag (6xHis). The recombinant protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_002183.4
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™
Uniprot: P26951
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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